Scientists on Wednesday announced the first effective treatment against the coronavirus — an experimental drug that can speed the recovery of COVID-19 patients — in a major medical advance that came as the economic gloom caused by the scourge deepened in the U.S. and Europe.

The U.S. government said it is working to make the antiviral medication remdesivir available to patients as quickly as possible.

“What it has proven is that a drug can block this virus,” said Dr. Anthony Fauci, the government's top infectious-disease expert. “This will be the standard of care.”

Stocks surged around the world on the news, with the Dow Jones Industrial Average gaining more than 530 points on the day, or over 2%.

Still, word of the new drug came as the U.S. government reported that American economic output is shriveling in the biggest and fastest collapse since the Depression. The virus has killed over 220,000 people worldwide, including more than 60,000 confirmed deaths in the U.S., and led to lockdowns and other restrictions that have closed factories and other businesses around the globe.

The U.S. said its gross domestic product, or output of goods and services, shrank at an annual rate of 4.8% in the January-March period, the sharpest quarterly drop since the global financial meltdown of more than a decade ago.

And the worst is yet to come: The Congressional Budget Office has estimated that the GDP of the world’s biggest economy will plunge at a 40% annual rate during the three-month period that ends in June.

The latest figures on people applying for unemployment benefits in the U.S. come out Thursday, with economists estimating perhaps 1 in 6 American workers, or nearly 30 million people, have lost their jobs over the past six weeks.

The U.S. unemployment rate for April will be released at the end of next week, and economists have said it could range as high as 20% — a level last seen during the Depression.

Mario Franco, who worked at a McDonald’s at a rest stop along Interstate 95 in Darien, Connecticut, for 26 years, rising to night manager in charge of the kitchen staff, was laid off in late March. The 50-year-old said he has little savings and now relies on a food bank and union donations.

“They didn’t give us any notice,” he said through an interpreter. “They didn’t tell us about it. Just suddenly the night shift ended and that was it. There was no more work.”

Amid the economic carnage, President Donald Trump was pushing to reopen the country, allowing federal social distancing guidelines to expire Thursday and even saying he plans to travel to Arizona next week.

Trump who in recent weeks had predicted the total U.S. virus death toll would come in at around the 60,000 milestone passed Wednesday, laid out plans for returning to pre-virus normalcy despite doctors’ warnings that the country will need to embrace extended social distancing and mask-wearing.

Confirmed infections globally reached about 3.2 million, including 1 million in the U.S., according to a tally by Johns Hopkins University. The true numbers of deaths and infections are believed to be much higher because of limited testing, differences in counting the dead and concealment by some governments.

California-based biotech company Gilead Sciences and the U.S. government reported that in a major study, remdesivir shortened the time it takes for COVID-19 patients to recover by four days on average — from 15 days to 11. Also, a trend toward fewer deaths was seen among those on the drug, Fauci said.

The study was run by the U.S. National Institutes of Health and involved 1,063 hospitalized coronavirus patients around the world.

An effective treatment could have a profound effect on the outbreak, since a vaccine is probably a year or more away.

Economic damage, meanwhile, is piling up around the world.

The United Nations’ main labor body predicted the world will lose the equivalent of about 305 million full-time jobs in the second quarter.

It also projected that 1.6 billion workers in the “informal economy,” including those working beyond the reach of the government, “stand in immediate danger of having their livelihoods destroyed.” That is nearly half the global workforce of 3.3 billion people.

In Europe, almost every measure of the economy is in free fall. Figures due to be released Thursday are expected to show a drop of about 4% in the first three months of the year in the eurozone, and an even steeper hit is projected this quarter. Unemployment is expected to rise to about 8%.

The figure would be worse if not for massive amounts of government aid to keep millions of workers on payrolls. Government debt is exploding to cover the costs of such relief.

“The lockdowns to contain the COVID-19 pandemic are taking an unprecedented toll on the European economy,” said Florian Hense, an economist at Berenberg Bank.

In Paris, aircraft maker Airbus reported a first-quarter loss of 481 million euros ($515 million), laid off thousands of workers and sought billions in loans to pull through the crisis. U.S.-based rival Boeing said it is cutting 10% of its workforce and reducing the production rate of commercial jets.

Italy’s credit rating was lowered in the first downgrade of a major economy as a result of the crisis. Its rating stands just one level above junk bond status. Italy expects its economy to shrink 8% this year.

Germany’s economy minister said the government is projecting a contraction of about 11% in GDP by the end of the quarter. But he also predicted a sharp recovery in 2021.

Many economists are skeptical the U.S. economy will bounce back quickly later in the year, noting that the virus could flare up again or consumers and employees might be too worried to return to business as usual.

“The virus has done a lot of damage to the economy, and there is just so much uncertainty now,” said Mark Zandi, chief economist at Moody’s Analytics.

In other developments, Britain raised its death toll to more than 26,000 after adding more than 3,800 nursing home deaths that were previously not included.

With the crisis easing in places like Italy, France and Spain, European governments are making adjustments in their transportation networks to try to get their economies running again without setting off a second wave of infections.

In Italy, Milan is putting red stickers on the floor to tell bus passengers how far apart to stand. The Dutch are putting on longer, roomier trains. Berlin and many other cities are opening up more lanes to bicyclists. And in Britain, bus passengers are using the middle or rear doors to reduce the risk to the driver.

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Associated Press journalists around the world contributed to this report.